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Bioprocessing controllers required for use and operation of single-use and reusable technologies include the Thermo Scientific HyPerforma GXCore, G3Lab, G3Lite, and G3Pro Controllers. These controllers incorporate innovative features that enhance productivity, data quality, and reproducibility required to optimize any process. Integrating flexibility and an open-architecture design, this platform allows the use of third-party vessels, as well as the Thermo Scientific Single-Use hardwares.