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Natural Products

Natural products have served as a major source for pharmaceutical and cosmetic products for many years. Besides that, they play a key role as ingredients for food and cosmetic applications. Due to their enormous variety, the methods used for development and production of these compounds is manifold.

DISCOVERY
The discovery of a natural product includes several steps.
The process begins with production of a crude extract from a natural source, which is used for a biological screening to identify a bioactive compound. Then, any target of interest gets further processed to achieve a single compound of high purity, which is tested thoroughly
for desirable characteristics and functions.
Development
Once an active ingredient has been identified, the development of the production process can begin. Here, the process is optimized on a larger scale to ensure a trouble-free production process. Before being incorporated into a final formulation, ingredients need to be preformulated in either a liquid or solid form to facilitate storage.
Formulation is used to protect the target material as well as for controlled or target release.
Testing
Natural products must undergo strict application testing before they enter the production process. The final product is typically tested for chemical stability and physical integrity under specific storage, transport, and use conditions. In case of pharmaceutical application,
clinical trials can take several years to complete and involve evaluating the drug mixture with animal, in vitro, and in vivo studies. If the product is proven safe and efficient, it can be released for production.
Production
nspection of incoming goods and final quality control ensures the desired quality of any natural product. Additionally, quality control during the production helps to analyze the identity, purity, and content of bulk material, intermediates, impurities, and degradation products. Close monitoring of the process enables safe operation and ensures the product meets the required specifications.

Steps for natural plant processing & products used

The first step in plant processing begins with cultivation. Close attention should be paid to managing moisture levels and reducing the risk of pesticide contamination.

Labotec IncoGrow Growth Chambers

This range of growth chambers have been designed for experimentation in the growth of plants, animals and insects.

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Fitotron HGC Modular Plant Growth Chambers

High Specification Plant Growth Chambers with optional growth areas

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Fitotron SGC Plant and Insect Growth Chamber

The Fitotron® SGC120 Plant and Insect Growth Chamber offers unsurpassed accuracy and reliability in the control of temperature, humidity and lighting. Larger plants of up to 1.5m can be grown inside the SGC120.

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Fitotron CGR Walk-in High Light Intensity Growth Rooms

The concept of the Fitotron® High Specification Growth Rooms (CGR’s) are based on application orientated modularity.

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Fitotron SGR walk-in Climate Rooms

Fitotron® Standard Growth Room (SGR’s) enable the researcher to maintain controlled growing conditions of temperature and/or humidity in a 24hr period with independent selection of photoperiods.

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Milling a wide variety of raw plant or biological materials requires flexible, modular, fast, and easy comminution. Important to the milling is the availability of different options of inlet sizes, collecting vessels, and stands exactly matched to your application.

Various methods of plant extraction to isolate the active substances are available and can be fine-tuned to your specifications.

FatExtractor E-500

Quick and Compliant

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UniversalExtractor E-800

Powerful & Perfect for Multitasking

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Large-scale rotary evaporators are commonly used to cover almost the entire range of solvent handling in plant production. Regardless of the method used for extraction, the solvent must be removed from the extract.

Rotavapor® R-300

The R-300 meets the highest expectations in convenience and versatility. Its modular design allows extension of the Rotavapor® R-300 to a fully integrated system where a central interface regulates each component.

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Flash chromatography is a suitable method for the separation and purification of different compounds of plant extract.

Pure C-850 Flash Prep

Fitting to your needs and environment

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Together with the Encapsulators for encapsulation of active ingredients, Spray Dryers for handling samples to produce the highest yields, our drying portfolio can be used for any R&D application in need of a highly efficient, versatile, and reproducible drying process.

Automation and innovative design of Buchi’s new spray dryer markedly improve spray drying performance

Fitting to your needs and environment

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B-395 PRO Encapsulator

Leading device for controlled encapsulation of cells, biological and active materials for labscale R&D work.

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